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Cocaine (C17H21NO4) is a powerfully addictive, psychoactive, stimulant drug. On the street it is usually sold as a fine, white powder. The powdered, hydrochloride salt form can be snorted or dissolved in water and injected. Use in any form is illegal in the U.S. when used as recreational drug.

Description

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What is cocaine?

Freebase is cocaine hydrochloride that is processed with ammonia and heated to remove the hydrochloride salt. This ‘freebase’ form is not water-soluble; the powder can be heated and its vapors smoked due to the lower melting point. Diethyl ether is used to process freebase and is highly flammable and volatile, often leading to lab explosions and bodily injury such as burns. Buy Cocaine Online, It produces a much more intense “rush” than snorting the drug and can be extremely addictive due to the quick high and repeated use. People who use this drug in any form may “binge” — taking the drug repeatedly within a short time and at increasingly higher doses — to maintain their high.

Crack cocaine (“crack”) is another form that is processed into a rock form using baking soda and may contain a high percentage of impurities. The term “crack” refers to the crackling sound heard when it is heated prior to smoking. Crack abuse in the U.S. rose in the mid-1980’s and is considered the most addictive form of the drug, Buy Cocaine Online.

Where does cocaine come from?

Cocaine originates from coca leaves, and has been used for centuries in a variety of cultural applications. The pure drug is extracted from the Erythroxylon coca bush, found primarily in the South American countries of Peru, Bolivia, and Colombia. Coca-leaf infusions or teas have been used to combat altitude sickness and boost energy in many native tribes of South America.

The early use was not just limited to South American countries. In the U.S., it was found as an active ingredient in many elixirs and tonics used in the early 1900’s and was even found as in Coca-Cola products at that time.

How is cocaine used medically?

It is available in the U.S. as a prescription solution for local mucosal anesthesia, and for some eye, ear, and throat surgeries, but is infrequently used because of safer alternatives, such as lidocaine or benzocaine. A nasal solution is used for the induction of local anesthesia of the mucous membranes when performing diagnostic procedures and surgeries on or through the nasal cavities in adults.

In the U.S. cocaine for is classified as a Schedule II controlled substance, meaning it has a high potential for abuse but can be administered by a physician for legitimate medical uses.

Methods of cocaine abuse

Most commonly abused by:

  • snorting up the nose
  • smoking
  • injection
  • rubbing onto the mucous membranes.

Cocaine hydrochloride (HCL) is water soluble due to the HCL salt and can be injected; it is also snorted in powder form. When purchased on the street, is usually ‘cut’ with adulterants such as baking soda, talcum powder, lactose sugar, or other local anesthetics such as lidocaine or benzocaine. This increases the weight and allows the seller to make more profit on the street. Other more dangerous adulterants, such as methamphetamine or synthetic opioids, including fentanyl, may also be used to cut the drug. Cutting cocaine with other illicit drugs can be especially harmful as the user is not aware of the added drug and an accidental overdose can occur.

Most often the powder is snorted, and the drug is laid out on a mirror, plate or other flat surface, separated into ‘lines’ and snorted nasally through a straw, rolled-up dollar bill or other inhaling device. The cocaine is absorbed into the bloodstream through the nasal tissues. The effect, or ‘high’ with snorting may last 15 to 30 minutes, but does not occur as quickly as smoking or injecting it. Alternatively, smoking crack or injecting cocaine may have a rapid and more intense effect, but the ‘high’ only lasts 5 to 10 minutes, often with an intense “crash”, which leads to repeated use to sustain the high, an action called ‘binging’.

Effects of cocaine use

The effect is described as euphoric with increased energy, reduced fatigue, and heightened mental alertness. Users may be talkative, extraverted, and have a loss of appetite or need for sleep. The psychoactive and pleasurable effects are short-lived without continued administration.

Biologically, the effect occurs in the midbrain region called the ventral tegmental area (VTA). Neuronal fibers from the VTA connect to the nucleus accumbens, an area of the brain responsible for rewards. Animals studies show that levels of a brain chemical (neurotransmitter) known as dopamine are increased in this area during rewards. Normally, dopamine is released and recycled in response to these rewards. The use of cocaine can interfere with this process, allowing dopamine to accumulate and send an amplified ‘reward’ signal to the brain, resulting in the euphoria described by users.

Some users report feelings of restlessness, irritability, and anxiety. A tolerance to the high may develop – many addicts report that they seek but fail to achieve as much pleasure as they did from their first exposure. Some users will increase their doses to intensify and prolong the euphoric effects. While tolerance to the high can occur, users can also become more sensitive to the anesthetic and convulsant effects without increasing the dose taken. This increased sensitivity may explain some deaths occurring after apparently low doses.

Use in a binge, during which the drug is taken repeatedly and at increasingly high doses, may lead to a state of increasing irritability, restlessness, and paranoia. This can result in a period of paranoid psychosis, in which the user loses touch with reality and experiences auditory hallucinations.

Metabolism of cocaine

Cocaine is metabolized primarily in the liver, with less than 1% of the parent drug being excreted in the urine. The primary metabolite is benzoylecgonine and it is detectable in the urine for up to eight days after consumption.

Health hazards

The immediate physical effects of cocaine use include constricted blood vessels, dilated pupils, and increased temperature, heart rate, and blood pressure. Health complications include:

  • disturbances in heart rhythm
  • headaches,
  • chest pain
  • respiratory failure
  • strokes
  • stomach pain and nausea
  • heart attacks
  • seizures

The various means of using this illicit drug can produce different adverse reactions:

  • Snorting the powder can lead to loss of the sense of smell, nosebleeds, problems with swallowing, hoarseness, and a chronically runny nose.
  • Ingesting it can cause severe bowel gangrene (tissue death) due to reduced blood flow.
  • Injecting the drug can lead to severe allergic reactions and, as with all IV drug users, an increased risk for contracting HIV, viral hepatitis and other blood-borne diseases.

Cocaine is a strongly addictive drug. Long-term effects of use can lead to tolerance, high doses and/or more frequent use is needed to attain the same level of pleasure during the initial period of use. Because it has a tendency to decrease appetite, many chronic users can become malnourished. If used in a binge fashion, with frequent, repeated use over a short period of time, panic and paranoia may set in, with psychosis and auditory hallucinations possible.

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